i-FACTOR Peptide Enhanced Bone Graft is the only osteobiologic that combines a small bioactive peptide, P-15, which replicates the cell-binding domain of human type I collagen, with an anorganic bone mineral (ABM). The unique combination creates a surface bound mechanism of action, which provides a microenvironment capable of supporting cell adhesion, proliferation and differentiation that enhances the body’s natural bone healing process [1-2].

Unlike engineered growth factors, i-FACTOR Bone Graft is not a morphogen and, being surface-bound, all cellular activity resulting from P-15 attachment is restricted to the implant surface so bone cannot grow where it doesn’t belong (ectopic bone growth). i-FACTOR provides a mechanism of action that is safe and predictable.

i-FACTOR Bone Graft is an advanced biologic that is supported with level I evidence, satisfies the highest regulatory imperatives, and provides a better cost/benefit ratio than engineered growth factors and cellular (stem cell) allografts.


1. Visser R, Rico-Llanos GA, Pulkkinen H, and Becerra J. Peptides for bone tissue engineering. J Control Release. 2016;244(Pt A):122-35.

2. Pountos I, Panteli M, Lampropoulos A, Jones E, Calori GM, and Giannoudis PV. The role of peptides in bone healing and regeneration: a systematic review. BMC Med. 2016;14:103.